Mission
Dyax’s mission is to discover, develop, and commercialize innovative biopharmaceuticals for unmet medical needs, while delivering outstanding value to patients and stockholders.

Strategy
Our therapeutic product candidates include fully human monoclonal antibodies as well as small proteins and peptides. Dyax is particularly focused on medical advances in the areas of oncology and inflammation. Our powerful discovery technology provides us the uncommon advantage of being able to both identify and then develop our own clinical leads. Our integrated approach also allows us to leverage this technology into revenue generating collaborations with other companies and researchers to further their own product pipelines.

History in Brief
The company was co-founded in 1995 by biotechnology entrepreneur Henry E. Blair, presently the Chairman, President and Chief Executive Officer of Dyax Corp. Dyax Corp. was formed by the merger between Biotage, a separations instrument chromatography firm, and Protein Engineering Corporation, from which we acquired our patented proprietary phage display technology. In 2003, Dyax sold its non-core business, Biotage, to focus exclusively on biotherapeutics.

Dyax Corp. issued an initial public offering (IPO) in August 2000 and is listed on the NASDAQ exchange (Ticker: DYAX).  Our company is headquartered in Cambridge, Massachusetts, and has antibody discovery facilities in Liege, Belgium.

Technology
Dyax’s core proprietary phage display technology allows for the rapid identification of compounds that bind with very high affinity and specificity to therapeutic targets. Utilizing phage display, we generate large diverse libraries of human antibodies, peptides, and proteins, which may be screened against disease-associated target molecules to identify potential binders. Automation allows us to rapidly screen these libraries for high-affinity binders. Our libraries’ vast size and diversity often yield multiple candidates, from which we can quickly select the single best therapeutic candidate.

Results
Dyax’s lead product candidate is DX-88, a recombinant small protein that is currently in clinical trials for its therapeutic potential in two separate indications. We have completed three Phase 2 trials and a Phase 3 trial of DX-88 for the treatment of hereditary angioedema (HAE). A second Phase 3 trial, known as EDEMA4, is ongoing and being conducted under a Special Protocol Assessment (SPA). DX-88 has orphan drug designation in the U.S. and E.U., as well as Fast Track designation in the U.S. for the treatment of acute attacks of HAE.

Additionally, Dyax has completed a Phase 1/2 trial of DX-88 for the prevention of blood loss during on-pump coronary artery bypass graft (CABG) procedures. A Phase 2 trial for further development of DX-88 in on-pump cardiothoracic surgery (CTS), including CABG and heart valve replacement or repair procedures, is ongoing.

In addition to supporting our own commercialization goals, Dyax leverages its technology broadly with more than 70 revenue generating licenses and collaborations for therapeutic discovery, as well as non-core areas such as affinity separations, diagnostic imaging and research reagents.

.