Protein Phage Display
Small Protein Libraries
Dyax has designed and built phage libraries based on well-characterized protein structures, for example, the first Kunitz domain of TFPI*, a human plasma protein. Dyax's approved product KALBITOR® (ecallantide) was identified using this library. (To find out more and to see Important Safety Information and Full Prescribing information, including Boxed Warning and Medication Guide, visit www.KALBITOR.com.)
A highly structured protein is selected and the amino acids in one portion of this "parental" protein are varied. Only those surface-accessible regions of the protein are varied because it is these regions that are available for binding of the target.
*Tissue Factor Pathway Inhibitor