Dyax - Advancing Novel Biotherapeutics

Publications

Publications

1. Vernon MK, Rentz AM, Wyrwich KW, White MV, Grienenberger A. Psychometric validation of two patient-reported outcome measures to assess symptom severity and changes in symptoms in hereditary angioedema.  Qual Life Res. 2009 Sep;18(7)929-39.
2. Sexton DJ, Chen T, Martik D, Kuzmic P, Kuang G, Chen J, Nixon AE, Zuraw BL, Forteza RM, Abraham WM, Wood CR. Specific inhibition of tissue kallikrein 1 with a human monoclonal antibody reveals a potential role in airway diseases.  Biochem J. 2009 Aug 13;422(2):383-92.
3. Devy L, Rabbani SA, Stochl M, Ruskowski M, Mackie I, Naa L, Toews M, van Gool R, Chen J, Ley A, Ladner RC, Dransfield DT, Henderikx P. PEGylated DX-1000: Pharmacokinetics and Antineoplastic Activity of a Specific Plasmin Inhibitor. Neoplasia. 2007 Nov; 9(11):927-37.
4. Schoonbroodt S, Steukers M, Viswanathan M, Frans N, Timmermans M, Wehnert Nguyen M, Ladner RC, Hoet RM.  Engineering antibody heavy chain CDR3 to create a phage display Fab library rich in antibodies that bind charged carbohydrates. J Immunol. 2008 Nov 1;181(9):6213-21. 
5. Buckler DR, Park A, Viswanathan M, Hoet RM, Ladner RC.  Screening isolates from antibody phage-display libraries.  Drug Discov Today. 2008 Apr;13(7-8):318-24.
6. Schneider L, Lumry W, Vegh A, Williams AH, Schmalbach T. Critical role of kallikrein in hereditary angioedema pathogenesis: A clinical trial of ecallantide, a novel kallikrein inhibitor. J Allergy Clin Immunol. 2007 Aug; 120(2):416-22
7. Levy JH, O'Donnell PS.  The therapeutic potential of a kallikrein inhibitor for treating hereditary angioedema. Expert Opin Investig Drugs. 2006 Sep;15(9):1077-90.
8. Nixon AE, Wood CR. Engineered protein inhibitors of proteases.  Curr Opin Drug Discov Devel. 2006 Mar; 9(2):261-8.
9. Wassaf D, Kuang G, Kopacz K, Wu QL, Nguyen Q, Toews M, Cosic J, Jacques J, Wiltshire S, Lambert J,Pazmany CC, Hogan S, Ladner RC, Nixon AE, Sexton DJ. High-throughput affinity ranking of antibodies using surface plasmon resonance microarrays. Anal Biochem. 2006 Apr 15;351(2):241-53.
10. Steukers M, Schaus JM, van Gool R, Hoyoux A, Richalet P, Sexton DJ, Nixon AE, Vanhove M. Rapid kinetic-based screening of human Fab fragments. J Immunol Methods. 2006 Mar 20;310(1-2):126-35.
11. Hoet RM, Cohen EH, Kent RB, Rookey K, Schoonbroodt S, Hogan S, Rem L, Frans N, Daukandt M, Pieters H, van Hegelsom R, Neer NC, Nastri HG, Rondon IJ, Leeds JA, Hufton SE, Huang L, Kashin I, Devlin M, Kuang G, Steukers M, Viswanathan M, Nixon AE, Sexton DJ, Hoogenboom HR, Ladner RC. Generation of high-affinity human antibodies by combining donor-derived and synthetic complementarity- determining-region diversity. Nat Biotechnol. 2005 Mar;23(3):344-8.
12. Jostock, Vanhove M, Brepoels E, Van Gool R, Daukandt M, Wehnert A, Van Hegelsom R, Dransfield D, Sexton D, Devlin M, Ley A, Hoogenboom H, Mullberg J. Rapid generation of functional human IgG antibodies derived from Fab-on-phage display libraries. J Immunol Methods. 2004 Jun;289(1-2):65-80.
13. Williams AH, Baird LG. DX-88 and HAE: a developmental perspective. Transfusion and Apheresis Science. Dec 2003;29(3):255-258.

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